& M! k. z1 ^* h. Ntvb now,tvbnow,bttvbBy Laurie Barclay, MD & @" d' K# G) I5 A6 \1 z2 y: W& A8 \Medscape Medical News 1 M# P% A8 \5 l5 j7 C# _& a) _tvb now,tvbnow,bttvb " ^2 e6 K$ f% [9 b% _2 D, P$ \公仔箱論壇January 8, 2009 — Antioxidant supplementation effectively relieves pain and oxidative stress in patients with chronic pancreatitis (CP), according to the results of a placebo-controlled, double-blind trial reported in the January issue of Gastroenterology. ' b$ R* _, G9 ?8 b+ Q$ {4 [) B5.39.217.77:8898 1 |) o: s0 Q: z9 Q公仔箱論壇"Oxidative stress has been implicated in the pathophysiology of...CP," write Payal Bhardwaj, from the All India Institute of Medical Sciences in New Delhi, and colleagues. "We evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant status in patients with CP." ( X8 m4 r4 h7 n0 d) oTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。 & s' j. F5 }5 J" z+ W' W3 |+ DConsecutive patients with CP were randomly assigned to receive placebo or antioxidant supplementation for 6 months, with the main endpoint of the study being pain relief. Secondary endpoints were a need for analgesics and hospitalization. Oxidative stress markers measured were thiobarbituric acid–reactive substances and antioxidant status (ferric-reducing ability of plasma). / p! ~0 W1 u% k' W. d) KTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。5.39.217.77:8898( R4 v" f+ E$ S4 _% \& s" z) }" r
Mean age of the patients was 30.5 ± 10.5 years, 86 were men, 35 had alcoholic CP, and 92 had idiopathic CP. Of 127 patients randomly assigned, 56 were in the placebo group and 71 in the antioxidant group. Compared with the placebo group, the antioxidant group had a significantly greater decrease after 6 months in the number of painful days per month (7.4 ± 6.8 vs 3.2 ± 4 days, respectively; P < .001; 95% confidence interval [CI], 2.07 - 6.23).tvb now,tvbnow,bttvb9 Q- L* b a$ k4 A- s
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The antioxidant group also had a greater reduction in the number of analgesic tablets taken per month (10.5 ± 11.8 vs 4.4 ± 5.8 tablets, respectively; P < .001; 95% CI, 2.65 - 9.65). The proportion of patients that became pain-free was 32% in the antioxidant group and 13% in the placebo group (P = .009).( }3 g& n9 k# n* O7 |
" |- a9 Y, g8 B6 K P2 Q& RCompared with the placebo group, the antioxidant group had a significantly greater reduction in the level of thiobarbituric acid–reactive substances and an increase in the ferric-reducing ability of plasma (thiobarbituric acid–reactive substances: placebo, 1.2 ± 2.7 nmol/mL vs antioxidant, 3.5 ± 3.4 nmol/mL; P = .001; 95% CI, 0.96 - 3.55; ferric-reducing ability of plasma: placebo, –5.6 ± 154.9 μMFe+2 liberated vs antioxidant 97.8 ± 134.9 μMFe+2 liberated; P = .001; 95% CI, 44.98 - 161.7). ! |$ Q$ G5 b* U! K3 e2 {! xTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。; `# o3 r4 \" s/ h7 I8 h
"Antioxidant supplementation was effective in relieving pain and reducing levels of oxidative stress in patients with CP," the study authors write. "Reduction in pain also resulted in fewer man-days lost, thus providing functional employment gain to the patients. The beneficial effect of antioxidants on pain relief was noted early — at 3 months."TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。( `! E; h( T7 i' w
6 V5 H7 T! s( C+ ]2 Y' FLimitations of the study include evaluation of pain subject to bias, reduction of pain in the placebo group, loss to follow-up, and lack of data concerning for how long the effect of antioxidants will last and for how long the antioxidant supplementation should be continued. ' x* w* q3 R, E/ v( @8 V / ]- {3 M" m5 S4 J0 h. L! D% T* wtvb now,tvbnow,bttvb"We did not observe any significant adverse drug reactions due to antioxidants in our study," the study authors conclude. "This could be due to the fact that the patients were antioxidant deficient. We believe that antioxidant therapy can be prescribed in an appropriate clinical setting of CP." 2 p2 Q! }- l; j2 O! P% J" G5 b( M! R; O* W2 s
This study was supported by Indian Council of Medical Research. Osper Pharmanautics provided the drug and placebo without charge. * G, i, y# q9 K; {. ]公仔箱論壇5.39.217.77:8898% S: `6 H) U) G$ |; N3 Y$ K. r3 B
Gastroenterology. 2009;136:149-159.
